GL-3 (RETA) Weight Loss Molecule and Consultation (1mL and 5mL Options)

GL-3 Molecule (Prescription Only)

Available in 10mg and 50mg Total Dose Vials

Triple-Incretin Therapy for Maximum Fat Loss, Appetite Control & Metabolic Reset

Formulations (All at 10mg / 1mL Concentration)

• GL-3 Core 10: 1mL vial containing 10mg total GL-3

• GL-3 Core 50: 5mL vial containing 50mg total GL-3

Classification: Prescription Only – Requires Provider Consultation & Approval

What Is GL-3 Therapy?

GL-3 is a prescription triple-incretin therapy that activates three complementary metabolic receptors:

• GLP-1 (glucagon-like peptide-1)

• GIP (glucose-dependent insulinotropic polypeptide)

• Glucagon receptor

By engaging all three pathways simultaneously, GL-3 therapy delivers the most comprehensive metabolic signaling currently available, supporting profound appetite suppression, accelerated fat oxidation, improved insulin sensitivity, and increased energy expenditure.

GL-3 represents the most advanced tier of incretin-based metabolic therapy, typically reserved for patients who have plateaued on GL-1 or GL-2 therapy or who require aggressive, provider-directed fat loss and metabolic intervention.

All GL-3 products provided by PROpeptides require a clinical consultation and prescription from a licensed providerprior to dispensing.

🔬 Key Research-Based Mechanisms

🔥 Triple-Incretin Activation for Superior Fat Loss

Simultaneous activation of GLP-1, GIP, and glucagon receptors enhances satiety, suppresses caloric intake, and accelerates adipose tissue breakdown.

Jastreboff et al., 2023 (NEJM)
– Demonstrated up to 24.2% total body-weight reduction over 48 weeks with triple-incretin therapy, the greatest weight loss reported to date in a pharmacologic trial.

🩸 Improved Glycemic Control & Insulin Sensitivity

GL-3 therapy lowers fasting glucose, improves insulin signaling, and significantly reduces HbA1c, making it particularly effective for patients with insulin resistance, prediabetes, or metabolic syndrome.

Frias et al., 2023 (Diabetes Care)
– Reported HbA1c reductions of up to 2.2%, with marked improvements in insulin sensitivity.

🧠 Appetite Suppression & Food Craving Reduction

GLP-1 and GIP activation reduce central appetite signaling, food reward response, and compulsive eating behaviors.

Killion et al., 2022
– Preclinical data demonstrated blunted hedonic drive and enhanced satiety with triple-incretin activation.

🧬 Enhanced Fat Oxidation & Energy Expenditure

Glucagon receptor activity increases metabolic rate and promotes fat oxidation while supporting lean mass preservation during weight loss.

Gil-Lozano et al., 2021
– Glucagon agonism maintained basal metabolic rate and increased fat utilization in metabolic models.

⚕️ Clinical Access & Prescription Protocol

GL-3 therapy is not available without a prescription and requires provider-directed oversight.

✔ Telehealth consultation required prior to dispensing
✔ Labs may be recommended (HbA1c, fasting glucose, IGF-1, lipid panel)
✔ Individualized dosing and titration plan
✔ Ongoing follow-up and clinical guidance included

💉 Dosing Protocol (Applies to All GL-3 Variants)

Each vial provides 10mg GL-3 per 1mL of solution. Vial size determines total available dose.

Typical Starting Dose: 20 units weekly (1 mg)

Titration Strategy:
• Increase by 10 units (0.5 mg) every 1–2 weeks only if tolerated and weight loss plateaus
• Reduce dose if side effects occur, then resume titration as directed

Route: Subcutaneous injection (abdomen preferred)
Duration: 3–6 months recommended, with reassessment every 4–8 weeks

Stack Compatibility: Commonly paired with KPV, Tesamorelin, MOTS-C, or GHK-Cu for enhanced metabolic efficiency, recovery, and body-composition support

📦 What’s Included With Every Order

✔ 1 × GL-3 Molecule vial (Core 10 or Core 50)
✔ Pre-measured bacteriostatic water
✔ Insulin syringes & alcohol swabs
✔ Sharps container bag
✔ Printed dosing, titration, storage, and injection guide
✔ Ongoing access to licensed prescribing provider

Need Assistance?
Email: Admin@Propeptides.com
Call/Text: 480-400-6225

🛡️ Advanced Fat Loss. Triple-Pathway Precision. Clinical Oversight.

GL-3 Core Therapy is designed for patients who need the highest level of metabolic intervention available. By activating three complementary incretin pathways, GL-3 delivers aggressive, provider-guided fat loss with structured monitoring and support.

Start with GL-3 Core 10.
Commit long-term with GL-3 Core 50.

All options include medical consultation and individualized dosing guidance.